"Chiral Self-Assembly in Lipid Tubules"
Relatore: Joel M. Schnur- Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375
05 Maggio 2003 ore 15.00
|Many types of amphiphilic molecules self-assemble in
solution to form cylindrical tubules and helical ribbons.
Some examples include diacetylenic lipids, amide
amphiphiles, bile, and diblock copolymers.
We have demonstrated a new approach for imaging nano scale
patterns on three-dimensional sub micrometer structures
using charged particles.
Nano particle structures were assembled onto lipid
tubules through the sequential adsorption of oppositely
charged polymers and silica spheres. These results give
new insight into the pattern of charge in lipid tubules.
Nano scale structures have been found to self-assemble in
a binary mixture of a long-chain, diacetylenic phospholipid
and a short chain, saturated lipid. Circular dichroism
results suggest that chiral packing of the lipids drives
formation of these aggregates. The ease of formation,
stability, and robust behavior of these lipid cylinders
suggest that they have potential use in applications
requiring high aspect ratio nano materials.